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Test ID: PPL Phospholipids, Serum

Reporting Name

Phospholipids, S

Useful For

First-order test in the diagnosis of lecithin-cholesterol acyltransferase deficiency

Specimen Type


Specimen Required

Patient Preparation:

1. Fasting-overnight (12-14 hours)

2. Patient must not consume any alcohol for 24 hours before the specimen is drawn.

Collection Container/Tube: 

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days

Reference Values

155-275 mg/dL

Reference values have not been established for patients who are <16 years of age.

Day(s) and Time(s) Performed

Monday through Friday; 7 a.m.-5 p.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PPL Phospholipids, S 2568-4


Result ID Test Result Name Result LOINC Value
PPL Phospholipids, S 2568-4

Clinical Information

The phospholipids comprise about 1/3 of the total lipids in serum. These consist in a large part of a lipid, phosphatidylcholine (formerly lecithin), in which 1 of the glycerol carbons is esterified with choline phosphate. A major step in lipoprotein particle remodeling results from lecithin-cholesterol acyltransferase (LCAT) activity, which normally transesterifies free cholesterol with fatty acids derived from phosphatidylcholine. LCAT deficiency results in a lack of remodeling of primary lipoprotein particles, affecting eventual cholesterol uptake and elimination. In cases of deficiency of LCAT, the concentration of lecithin in the serum are increased several-fold.


Clinical findings in LCAT deficiency include corneal opacities, anemia, and frequently, proteinuria. The disorder is inherited as an autosomal recessive trait. Early atherosclerosis develops in many individuals with this disorder.


In addition, sphingomyelin normally comprises about 5% to 20% of the total phospholipids of serum. In Niemann-Pick Type A and B diseases, sphingomyelin accumulates in visceral and neural tissues and may become increased in the serum.


Other disorders involving alterations of the concentration, composition, and/or lipoprotein distribution include: abeta- or hypobetalipoproteinemia, Tangier disease, or fish eye disease.


Elevated in cases of lecithin-cholesterol acyltransferase deficiency deficiency due to elevations of lecithin

Clinical Reference

1. Baehorik PS, Levy RI, Rifkind BM: Lipids and dyslipoproteinemia. In Clinical Diagnosis and Management by Laboratory Methods. 18th Edition. Edited by JB Henry. Philadelphia, WB Saunders Company, 1991, p 198

2. Norum KR, Gjone E, Glomset JA: Familial lecithin: cholesterol acyltransferase deficiency, including fish eye disease. In The Metabolic Basis of Inherited Disease. Sixth Edition. Edited by CR Scriver, AL Beaudet, WS Sly, D Valle. New York, McGraw-Hill Book Company, 1989, pp 1181-1194

Analytic Time

1 day (not reported on Saturday or Sunday)

Method Name

Enzymatic Colorimetric


If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen (

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