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Test ID: MYGLU Myoglobin, Random, Urine


Specimen Required


Supplies: Urine Myoglobin Transport Tube (T691)

Container/Tube: Plastic, 10-mL urine myoglobin transport tube

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a preservative-free, random urine specimen.

2. If specimen is at ambient temperature, aliquot the urine to a urine myoglobin transport tube (T691) within 1 hour of collection. Refrigerate specimen.

3. If specimen is refrigerate, aliquot the urine to a urine myoglobin transport tube (T691) within 2 hours of collection.

Additional Information: Urinary myoglobin is highly unstable unless alkalinized with sodium carbonate preservative. Even with alkalinization, myoglobin deterioration is variable and specimen dependent (approximate averages of 10% at 1 day, 20% at 3 days, and 30% at 7 days).


Useful For

Confirming the presence of a myopathy associated with any 1 of the following disorders

-Hereditary myoglobinuria

-Phosphorylase deficiency

-Sporadic myoglobinuria

-Exertional myoglobinuria in untrained individuals

-Crush syndrome

-Myocardial infarction

-Myoglobinuria of progressive muscle disease

-Heat injury

 

May suggest a myopathic cause for acute renal failure

Method Name

Latex Particle-Enhanced Immunoturbidometric Assay

Reporting Name

Myoglobin, Random, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated 7 days MYOGLOBIN TRANSPORT TUBE

Clinical Information

Myoglobin is the oxygen-binding protein of striated muscle. Injury to skeletal or cardiac muscle results in the release of myoglobin. High concentrations appear very rapidly in the urine in various conditions including some metabolic diseases.

 

Conditions associated with myoglobinuria include:

-Hereditary myoglobinuria

-Phosphorylase deficiency

-Sporadic myoglobinuria

-Exertional myoglobinuria in untrained individuals

-Crush syndrome

-Myocardial infarction

-Myoglobinuria of progressive muscle disease

-Heat injury

 

Urine myoglobin increases with muscle necrosis, but the clinical consequences are variable. Therefore, myoglobin can confirm a clinical diagnosis of myopathy, but an elevated urine excretion of myoglobin is not specific for a clinical disorder.

 

In acute renal failure, an elevated urinary myoglobin can suggest a potential cause and, consequently, may indicate appropriate treatment courses.

Reference Values

≤65 mcg/L for 18-83 years of age

Reference values have not been established for patients<18 or >83 years of age.

Interpretation

Increased excretion of urinary myoglobin is suggestive of 1 of the following disorders:

-Hereditary myoglobinuria

-Phosphorylase deficiency

-Sporadic myoglobinuria

-Exertional myoglobinuria in untrained individuals

-Crush syndrome

-Myocardial infarction

-Myoglobinuria of progressive muscle disease

-Heat injury

 

Most clinically significant elevations are elevated 2 to 10 times normal.

 

Visual pigmenturia occurs at myoglobin concentrations about 200 times normal (approximately 4000 mcg/L).

 

Renal toxicity depends on multiple factors such as renal perfusion and degree of acidity of urine.

Clinical Reference

1. Rowland LP: Myoglobinuria. Can J Neurol Sci. 1984;11:1-13

2. Tonin P, Lewis P, Servidei S, DeMauro S: Metabolic causes of myoglobinuria. Ann Neurol. 1990;27:181-185

3. Dawley C: Myalgias and myopathies: rhabdomyolysis. FP Essent. 2016 Jan;440:28-36

4. Nance JR, Mammen AL: Diagnostic evaluation of rhabdomyolysis. Muscle Nerve. 2015 Jun;51(6):793-810. doi: 10.1002/mus.24606

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Analytic Time

1 day

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83874

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MYGLU Myoglobin, Random, U 2641-9

 

Result ID Test Result Name Result LOINC Value
MYGLU Myoglobin, Random, U 2641-9