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Test ID: MYGLS Myoglobin, Serum

Reporting Name

Myoglobin, S

Useful For

Assessing muscle damage from any cause

Specimen Type

Serum


Specimen Required


Collection Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

≤90 mcg/L

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83874

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MYGLS Myoglobin, S 2639-3

 

Result ID Test Result Name Result LOINC Value
MYGLS Myoglobin, S 2639-3

Clinical Information

Myoglobin is a heme protein found in smooth and skeletal muscles. Serum myoglobin reflects a balance between intravascular release of myoglobin from muscle and renal clearance.

 

Previously serum myoglobin had been advocated as a sensitive marker for early acute myocardial injury (eg, acute myocardial infarction: AMI). However, more recent studies indicate that other newer markers (eg, troponin) provide superior diagnostic utility in detecting early myocardial injury.

 

Elevation of serum myoglobin may occur as a result of muscle trauma, resuscitation, myopathies, AMI, shock, strenuous body activity, or decreased elimination during renal insufficiency. Extreme elevations occur in rhabdomyolysis.

Interpretation

Elevated myoglobin levels are seen in conditions of acute muscle injury.

Clinical Reference

1. Lamb EJ, Jones GRD: Kidney functions tests. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:489

2. Cappenllini MD, Lo SF, Swinkels DW. Hemoglobin, iron, bilirubin. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:747

3. Varki AP, Roby DS, Watts H, Zatuchni J: Serum myoglobin in acute myocardial infarction: a clinical study and review of the literature. Am Heart J. 1978;96:680-688

4. Kallner A, Sylven C, Brodin U, et al: Early diagnosis of acute myocardial infarction. A comparison between chemical predictors. Scand J Clin Lab Invest. 1989;49:633-639

Analytic Time

1 day

Method Name

Latex Particle-Enhanced Immunoturbidometric Assay