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HelpTest ID: CRMP1 Cardiovascular Risk Marker Panel, Serum
Specimen Required
Patient Preparation: Fasting is preferred but not required unless directed by the ordering provider.
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 2.5 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial. Send refrigerated.
Useful For
Assessment for risk of developing cardiovascular disease, major adverse cardiovascular events, or ischemic cerebrovascular events
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CLDL1 | Cholesterol, LDL, Calculated, S | No | Yes |
| NHDCH | Cholesterol, Non-HDL, Calculated, S | No | Yes |
| APOLB | Apolipoprotein B, S | Yes | Yes |
| HDCH | Cholesterol, HDL, S | Yes | Yes |
| CHOL | Cholesterol, Total, S | Yes | Yes |
| TRIG | Triglycerides, S | Yes | Yes |
| LIPA1 | Lipoprotein(a), S | Yes | Yes |
| HSCRP | C-Reactive Protein, High Sens, S | Yes | Yes |
| CVINT | Interpretation | No | Yes |
| INTC1 | Fasting (8 HR or more) | No | Yes |
Method Name
LIPA1, HSCRP, APOLB: Immunoturbidimetry Assay
CHOL, TRIG, HDCH: Enzymatic Colorimetric
CLDL1, HNDCH: Calculation
Reporting Name
Cardiovascular Risk Marker Panel, SSpecimen Type
SerumSpecimen Minimum Volume
1.25 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 30 days |
Clinical Information
Lipoprotein cholesterol measures are essential in managing risk for atherosclerotic cardiovascular disease (ASCVD). Atherosclerosis is defined by a buildup of plaque within arterial walls. ASCVD includes coronary heart disease, strokes, and peripheral artery disease. ASCVD develops over decades and is often asymptomatic until the patient experiences a life-threatening event such as a heart attack, stroke, or aneurysm.
Cholesterol is a lipid that is synthesized in most tissues and actively absorbed from the diet. There is a strong association between serum cholesterol concentrations and cardiovascular disease. Cholesterol is carried in the blood by lipoproteins. Some lipoproteins carry a stronger risk of cardiovascular disease while others are associated with reduced cardiovascular risk. Total cholesterol concentration includes the sum of all "good" and "bad" cholesterol. Therefore, total cholesterol is recommended to be interpreted in context of a lipid panel that includes high-density lipoprotein cholesterol (HDL-C) and triglyceride measures.
Low-density lipoprotein cholesterol (LDL-C) is the primary lipoprotein responsible for atherogenic plaque. Very low-density lipoprotein cholesterol (VLDL-C) is also atherogenic and the combination of LDL-C and VLDL-C is called non-HDL-C and often referred to as "bad" cholesterol. Serum total cholesterol, LDL-C and non-HDL-C are all directly associated with risk for ASCVD.
HDL-C is associated with lower risk of cardiovascular disease. Excess cholesterol is actively pumped into HDL to be carried in the blood circulation and cleared by the liver in a process known as reverse cholesterol transport. For these reasons, HDL-C is often referred to as "good" cholesterol.
Triglycerides are oily lipids carried in the blood by lipoproteins. Triglycerides are primarily carried by VLDL, chylomicrons and remnant lipoproteins. Recent evidence supports triglycerides as an independent risk factor for ASCVD. Several conditions are associated with increased plasma triglycerides, including obesity, pregnancy, physical inactivity, excess alcohol intake, kidney disease, and diabetes. Elevated triglycerides are often associated with reduced HDL-C, insulin resistance, hypertension, fatty liver disease, and increased waist circumference. In addition to cardiovascular risk, elevated triglycerides confer a risk for acute pancreatitis.
Apolipoprotein B (ApoB), high-sensitivity C-reactive protein (hsCRP), and lipoprotein (a) (Lp[a]) are serological risk factors endorsed by multiple international guidelines for use in cardiovascular disease risk assessment. Several recent guidelines have suggested that clinicians utilize ApoB, hsCRP, and Lp(a) in selected persons to augment risk classification, guide intensity of risk-reduction therapy, and modulate clinical judgment when making therapeutic decision.(1-3)
Reference Values
|
Age |
2-17 years |
≥18 years |
|
CALCULATED NON-HDL CHOLESTEROL (mg/dL) |
** Acceptable: <120 Borderline High: 120-144 High: ≥145 |
* Desirable: <130 mg/dL Above Desirable: 130-159 mg/dL Borderline High: 160-189 mg/dL High: 190-219 mg/dL Very high: ≥220 mg/dL |
|
CALCULATED LDL CHOLESTEROL (mg/dL) |
** Acceptable: <110 Borderline High: 110-129 High: ≥130 |
*** Desirable: <100 Above Desirable: 100-129 Borderline High: 130-159 High: 160-189 Very high: ≥190 |
|
HDL CHOLESTEROL (mg/dL) |
** Low: <40 Borderline Low: 40-45 Acceptable: > 45 |
*** Males: ≥40 Females: ≥50
|
|
TOTAL CHOLESTEROL (mg/dL) |
** Acceptable: <170 Borderline High: 170-199 High: ≥200 |
* Desirable: < 200 Borderline High: 200 - 239 High: ≥ 240 |
|
LIPOPROTEIN (a) (nmol/L) |
Not established |
< 75 nmol/L Values ≥ 75 nmol/L may suggest increased risk of coronary heart disease. |
|
C-REACTIVE PROTEIN, HIGH SENSITVITY |
* Lower risk: <2.0 mg/L Higher risk: ≥2.0 mg/L Acute inflammation: >10.0 mg/L |
* Lower risk: <2.0 mg/L Higher risk: ≥2.0 mg/L Acute inflammation: >10.0 mg/L |
|
APOLIPOPROTEIN B(mg/dL) |
Acceptable: <90 Borderline High: 90-109 High: ≥110 |
Desirable: <90 Above Desirable: 90-99 Borderline High: 100-119 High: 120-139 Very High: ≥140 |
|
Age |
2-9 years |
10-17 years |
≥18 years |
|
TRIGLYCERIDES (mg/dL) |
** Acceptable: <75 Borderline High: 75-99 High: ≥100 |
** Acceptable: <90 Borderline High: 90-129 High: ≥130 |
* Normal: <150 Borderline High: 150-199 High: 200-499 Very High: ≥500 |
*National Lipid Association 2014
**Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents
***National Cholesterol Education Program (NCEP)
Interpretation
Maintaining desirable concentrations of lipids lowers atherosclerotic cardiovascular disease risk. Establishing appropriate treatment strategies and lipid goals require that blood lipid values be considered in context with other risk factors including, age, sex, smoking status, and medical history of hypertension, diabetes, and cardiovascular disease.
Triglycerides results of 500 mg/dL or above are severely elevated increasing the risk of pancreatitis.
Triglycerides can be lowered by increasing physical activity, low-fat diet, weight loss and/or triglyceride lowering pharmaceuticals.
Low high-density lipoprotein cholesterol (HDL-C) is a risk factor for cardiovascular disease.
HDL-C can be increased by the same lifestyle changes that reduce risk for cardiovascular disease; physical activity, smoking cessation, and eating healthier. However, medications that specifically increase HDL levels have failed to reduce cardiovascular disease.
Extremely low HDL values (<20 mg/dL) may indicate liver disease or inherited dyslipidemia.
Low-density lipoprotein cholesterol results of 190 mg/dL or above in adults (≥160 mg/dL in children) are severely elevated and may indicate familial hypercholesterolemia.
For non-HDL cholesterol results of 220 mg/dL or above, consider possible inherited hyperlipidemia.
Clinical Reference
1. Grundy SM, Stone NJ, Bailey AL, et al: 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019 Jun 18;139(25):e1082-e1143
2. Jacobson TA, Ito MK, Maki KC, et al: National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1-executive summary. J Clin Lipidol. 2014 Sep-Oct;8(5):473-488. doi: 10.1016/j.jacl.2014.07.007
3. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: Summary report. Pediatrics. 2011 Dec;128 Suppl 5(Suppl 5):S213-S256. doi: 10.1542/peds.2009-2107C
4. Sampson M, Ling C, Sun Q, et al: A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and/or hypertriglyceridemia. JAMA Cardiol. 2020 May 1;5(5):540-548
Day(s) Performed
Report Available
1 to 2 daysTest Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80061-Lipid panel (includes: HDL [CPT Code 83718], total cholesterol [CPT Code 82465], and triglycerides [CPT Code 84478])
83695-Lipoprotein (a)
86141-C-reactive protein; high sensitivity (hsCRP)
82172-Apolipoprotein B
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CRMP1 | Cardiovascular Risk Marker Panel, S | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CVINT | Interpretation | 59462-2 |
| APOLB | Apolipoprotein B, S | 1884-6 |
| LIPA1 | Lipoprotein(a), S | 43583-4 |
| CLDL1 | Cholesterol, LDL, Calculated, S | 13457-7 |
| INTC1 | Fasting (8 HR or more) | 87527-8 |
| CHOL | Cholesterol, Total, S | 2093-3 |
| HDCH | Cholesterol, HDL, S | 2085-9 |
| HSCRP | C-Reactive Protein, High Sens, S | 30522-7 |
| NHDCH | Cholesterol, Non-HDL, Calculated, S | 43396-1 |
| TRIG | Triglycerides, S | 2571-8 |
Forms
If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen.
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